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Testing of endocrine Properties according OECD

The endocrine disruptors (endocrine disrupting compounds EDCs) have become an increasing focus for the public, since they show already in the lowest concentrations hormone-like effects on organisms in the environment and on human.

2002 the OECD Conceptual Framework for the Testing and Assessment of Endocrine Disrupting Chemicals was introduced by the EDTA (OECD Endocrine Disrupter Testing and Assessment Task Force), which specifies five different investigation levels for the risk assessment of endocrine disrupting chemicals:

Level 1

Sorting & prioritization based upon existing information

 

Level 2

In vitro assays providing mechanistic data

 

Level 3

In vivo assays providing data about single endocrine
Mechanisms and effects

 

Level 4

In vivo assays providing data about multiple endocrine
Mechanisms and effects

 

Level 5

In vivo assays providing data on effects from endocrine &
other mechanisms

 

We support you in testing your substance on endocrine disrupting properties with the following studies:

Level 2

  • Estrogen or androgen  receptor binding affinity (YES/YAS Assay)

Level 4

  • Fish Sexual Development Test (OECD 234)
  • Fish Reproduction Partial Lifecycle Test
  • Sediment-Water Chironomid Toxicity Using Spiked Sediment (OECD 218)
  • Sediment-Water Chironomid Toxicity Using Spiked Water (OECD 219)
  • Daphnia Reproduction Test (OECD 211)
  • Earthworm Reproduction Test (OECD 222)
  • Sediment Water Lumbriculus Toxicity Test (OECD 225)

Level 5

  • Fish Life Cycle Test (Danio rerio) (OECD DRP 2008)

The study you need is not listed? Please contact us.