Environmental impact assessment for veterinary medicinal products (VMP)  according CVMP/VICH/790/03-FINAL

Phase II: Tier A

Physico-chemical Properties

• UV/VIS absorption spectra
• Melting point / Melting range
• Water solubility
• Partition Coefficient log Kow
• Dissociation constant in water
• Vapour pressure (calculation)

Terrestrial Ecotoxicology

• Nitrogen transformation
• Terrestrial plants growth
• Earthworm subacute / reproduction

Environmental Fate 

• Biodegradation (soil or aquatic)
• Adsorption / Desorption in soil Kd / Koc
• Photolysis (optional)
• Hydrolysis (optional)

Aquatic Ecotoxicology

• Algae growth inhibition
• Daphnia immobilisation
• Fish acute toxicity
  (Additional salt water test systems  for products used for aquaculture)

Phase II: Tier B

Depending on the results of the studies from Tier A, additional studies are necessary:

• Environmental Fate
• Terrestrial Ecotoxicology
• Aquatic Ecotoxicology

Assessment of Environmental Safety for Veterinary Medicinal Products