Small enough to care and big enough to deliver

Alternative test methods to animal testing have become of enormous relevance over the last years. Thus, for example in vivo studies in the cosmetics industry are completely prohibited since 2013. Also in many other product fields, it is has become very difficult to obtain permits for animal studies. Through intensive research and global studies, the range of in vitro methods could be numerically but also qualitatively extended enormously in the last years. Today a reliable reproducibility with appropriate in vivo studies exists.

Thus, in vitro toxicology represents a very important field which will become of enormous relevance in the next few years. For the examination of irritating or corrosive properties according to the categorization of Globally Harmonized System (GHS), we offer a number of in vitro tests on skin and eye.

A selection of the suitable test systems often depends on the test substance as well as the regulatory requirements. We would be pleased to advice you in this.

in vitro Skin Tests
Guideline Description

 OECD 431

Skin Corrosion: "In Vitro Skin Corrosion: Reconstructed Human Epidermis Test Method"

 OECD 435

Skin Corrosion : "In Vitro Membrane Barrier Test Method for Skin Corrosion" (Corrositex)

 OECD 439

Skin Irritation: "In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method"

 

in vitro Eye Tests
Guideline Description

OECD 437

Serious Eye Damage: "Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage" (BCOP)

OECD 492

Eye Irritation: EpiOcularTM Irritation

 

Eye Irritation: HET CAM Test

 

in vitro Skin Sensitization
Guideline Description
OECD 442D

LuSens - In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method in accordance to the OECD 442D

OECD 442C

In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA)

 

 

Cytotoxicity
Guideline Description
ISO 10993-5 Cytotoxicity; Growth Inhibition Test

 

Endocrine Properties
Guideline Description
  Estrogen- and Androgen Receptor Binding Affinity - YES/YAS Assay

The study you need is not listed? Please contact us. We’ll prepare you an individual offer for your needs.